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Title: Targeting cytokine systems to achieve neuroprotection : experimental models of seizures and neurodegeneration
Author: Balosso, Silvia
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2009
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This study investigated whether IL-1β and TNF-α have a role in the pathophysiology of seizures by altering neuronal excitability and cell survival and also probed new targets to achieve an effective anticonvulsive action. The first set of experiments evaluated if acute and spontaneous seizures can be effectively inhibited by blocking the brain production of IL-1β using a selective inhibitor of caspase-1, the key enzyme specifically involved in the production of the releasable and biologically active form of IL-1β. Caspase-1 inhibition significantly reduced the number and the total time spent in seizures, indicating that this treatment represents an effective and novel anticonvulsive strategy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available