Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496851
Title: The synthesis and methodology development of novel (2.2) paracyclophane based compounds
Author: Seacome, Richard John
Awarding Body: UNIVERSITY OF SUSSEX
Current Institution: University of Sussex
Date of Award: 2009
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Abstract:
This thesis contains 7 chapters detailing the background, uses and syntheses of novel [2.2]paracyclophane compounds. Where applicable, their use in asymmetric synthesis is described. Within chapter 1, a brief description of the history of [2.2]paracyclophane and the development of its chemistry is given, this includes its basic reactivity and that of its derivatives. A short introduction of its use in asymmetric synthesis is also included. Finally, a very brief review of novel applications of the [2.2]paracyclophane motif in polymer and medicinal chemistry is given. Chapter 2 outlines the synthesis of (S)-4-butylsulfinyl[2.2]paracyclophane and the subsequent extensive optimisation of directed metalation conditions. A summary of the analytical data and syntheses of 11 novel 4,5-disubstituted [2.2]paracyclophane compounds is presented.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.496851  DOI: Not available
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