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Title: Effect of dioxin on bone cell proteome
Author: Carpi, Donatella
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2009
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Is an endocrine disrupting environmental pollutant that affects bone tissue, although the mechanistic basis of such effect is far from clear. In this study a proteomic approach has been adopted to Investigate the disturbance of the osteogenic process evoked by TCDD In an in vitro osteoblast differentiation model of rat mesenchymal stem cells. Stem cells were isolated from bone marrow of femurs and tibias of rats. Progress of osteoblastic differentiation was monitored by measuring mRNA expression levels of differentiation markers from control and TCDD-treated cells after 3,7 and 10 days of culture In presence and absence of TCDD using quantitative RT-PCR.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available