Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495782
Title: Descending control of nociception : a role for the cyclooxygenase pathway in the periaqueducatal grey
Author: Leith, Jessica Lianne
Awarding Body: UNIVERSITY OF BRISTOL
Current Institution: University of Bristol
Date of Award: 2008
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Abstract:
The midbrain periaqueductal grey (PAG) has been extensively studied with respect to descending control of nociception and is classically viewed as a source of descending inhibition, resulting in antinociception at the level of the spinal cord. However, recent studies suggest that facilitation can also be evoked from the PAG and descending facilitation from brainstem sites is hypothesised to contribute to the generation and maintenance of chronic pain. Recent work from this laboratory has demonstrated that descending control from the PAG discriminates between spinal processing of A- and C-nociceptive inputs. This has important consequences given the different roles of A- and C- nociceptors in physiological and pathophysiological pain.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.495782  DOI: Not available
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