Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495780
Title: The roles of presenilin-1 and proNGF in the cholinergic theory of Alzheimer's disease
Author: Hatchett, Caroline Sara
Awarding Body: UNIVERSITY OF BRISTOL
Current Institution: University of Bristol
Date of Award: 2008
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Abstract:
The cholinergic neurons of the basal forebrain are vulnerable in Alzheimer's disease (AD). These neurons require trophic support by nerve growth factor (NGF) and, uniquely in the brain, express both NGF receptors: TrkA and p75NTR. Reduced support by NGF has been associated with neuronal loss and formation of amyloid plaques and neurofibrillary tangles. This study aimed to increase understanding of proNGF trophic signalling via TrkA/p75NTR and its impact on cholinergic survival in sporadic AD.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.495780  DOI: Not available
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