Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495606
Title: The role of galanin in early mouse development and embryonic stem cells
Author: Razavi, Janet
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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Abstract:
Galanin is a secreted neuropeptide which is highly conserved between species and is abundantly distributed in the central nervous system (CNS). One of the most significant changes following axotomy or nerve injury is the upregulation of LIF followed by a 120 fold increase in Galanin expression, which remains elevated during the regeneration of the netve. LIF followed mice have significant reduction in Galanin expression in neurons and impaired nerve regeneration compared to wild type mice. This suggests that Galanin and LIF may be involved in nerve regeneration and that the absence of one or both genes may lead to impaired neurogenesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.495606  DOI: Not available
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