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Title: The Holliday junction as a therapeutic target : synthetic and structural studies of the interactions of small molecules with nucleic acid structures
Author: Brogden, Ann L.
ISNI:       0000 0001 3481 2531
Awarding Body: The University of Reading
Current Institution: University of Reading
Date of Award: 2006
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This work describes the interactions of small molecules with nucleic acid structures. Chapter 1 is concerned with the structure of DNA and goes on to explain the , structure of the DNA Holliday junction, an Intermediate in homologous recombination. Chapter 2 explains why the DNA Holliday junction is a potential therapeutic target for small molecules in the disruption of certain pathways utilizing homologous recombination. Chapter 3 goes on to describe the process of ligand design with the development of the bls(9-amlnoacrldlne-4carboxamides) as potential junction binders. Chapter 4 is concerned with DNA crystallography as a method to exami small molecule binding to nucleic acid structures.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available