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Title: Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
Author: Vugler, Alexander David
ISNI:       0000 0001 3549 3827
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2008
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Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thesis addressed some of these issues by developing short-term mechanistic models of collagen II (CII) immunity. Drug effects on Cll-induced hypersensitivity, anti-CII antibodies and ex vivo CII stimulated CD4⁺ T cell proliferation in mice 14 days post-CII sensitisation were assessed and compared to their anti-arthritic effect in CIA.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available