Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494505
Title: Target site selection of retroviral vectors in the human genome : viral and genomic determinants of non-random integration patterns in hematopoietic cells
Author: Cattoglio, Claudia
ISNI:       0000 0001 3525 2636
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2008
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Abstract:
Integration of gamma-retroviruses (RV) and lehtiviruses (LV) follows different, non random patterns in mammalian genomes. To obtain information about the viral and genomic determinants of integration preferences, I mapped > 2,500 integration sites of RV and LV vectors carrying wild type or modified LTRs in human CD34+ hematopoietic cells. To investigate the role of transcriptional regulatory networks in directing RV and LV integration, 1 evaluated the local abundance and anangement of putative transcription factor binding sites (TFBSs) in the genomic regions flanking integrated proviruses.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.494505  DOI: Not available
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