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Title: The role of hepatocyte nuclear factor 4α (HNF4α) in the metabolic regulation of its target genes
Author: Devonshire, Alison
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2009
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The nuclear receptor Hepatocyte Nuclear Factor 4α (HNF4α; NR2A1) regulates the transcription of many genes involved in glucose and lipid metabolism. Genetic linkage analyses have implicated HNF4α in the disease processes leading to Type 2 Diabetes Mellitus and dyslipidaemia. The aim of this study was to investigate the regulation of tf target genes in the metabolic pathways of glycolysis, lipogenesis and gluconeogenesis by HNF4α.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available