Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494099
Title: Neutrophil signalling via Fcγ receptors
Author: Allen, John Cronin
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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Abstract:
It has previously been shown that removal or blocking of the neutrophil receptor, FcyRIIIb (CD16b) completely prevented the ability of neutrophils to secrete reactive oxidants and granule enzymes in response to soluble immune complexes (SIC), but had no effect on the phagocytosis and killing of serum-opsonised Staphylococcus aureus. As soluble immune complexes are the major neutrophil activating factors in the synovial fluids of patients with rheumatoid arthritis, the aim of this work is to determine the intracellular signalling pathways regulated by FcYRIIIb to understand, in more detail, neutrophil function in disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.494099  DOI: Not available
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