Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494000
Title: Role of ERα and ERβ in oestrogen action in human breast cancer cells
Author: Pugazhendhi, Dhamayanthi
ISNI:       0000 0001 3502 6778
Awarding Body: Reading University
Current Institution: University of Reading
Date of Award: 2007
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Abstract:
The role of ERα in hormone responsive breast cancer is well established but that of ERβ remains to be determined. In this thesis, the effects of overexpression of ERβlong have been studied in MCF7 human breast cancer cells which possess high endogenous levels of ERα . Stable overexpression of ERβlong protein (2-fold) resulted in reduced fold induction (from 2.6 to 1.8) of an ERE-CAT reporter gene with 10-8M 17β-oestradiol but enhanced fold induction (from 1.18 to 2.12) by 10-5M genistein and an increased induction (from 4.4 to 11.4) of growth with 10-4M methylparaben.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.494000  DOI: Not available
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