Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493233
Title: Role of replisome proteins in recognition of deaminated bases in Archaea
Author: Emptage, Kieran
ISNI:       0000 0001 3447 7438
Awarding Body: Newcastle University
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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Abstract:
Family B DNA polymerases from archaea, such as Pyrococcus furiosus (Pfli-Pol), stall replication upon encountering template strand uracil and hypoxanthine (the deamination products of cytosine and adenine spectively) four base pairs ahead of the primer template junction. The deaminated bases bind to a specialized pocket within the amino terminal domain of the polymerase. This read-ahead mechanism could be a final attempt to detect deaminated bases and repair them by an as yet undetermined pathway, preventing 50% of the progeny inheriting a transition mutation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.493233  DOI: Not available
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