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Title: An investigation into the ligand dependent regulation of the nuclear receptor PXR (NR1I2) and its target genes
Author: Bailey, Ian
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2008
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The study of absorption, distribution, metabolism and excretion (ADME) of compounds within the body is of vital importance to health. PXR is a nuclear receptor which regulates the expression of a great many ADME genes and is responsible for the regulation of all parts of the ADME of many compounds. It is believed that the nuclear receptors, including PXR, activate genes on a ligand dependent basis, a mechanism which is probably regulated by the recruitment of a different battery of co-regulator proteins. The ligand dependent selection of genes by recruitment of alternate co-regulator complexes has not yet been directly demonstrated. The co-regulator proteins of PXR are not well characterised although co-regulator complexes of other receptors, including the oestrogen receptor, growth hormone receptor and retinoic acid receptor are comparatively well characterised.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available