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Title: Comparing the metabolism and metabolic capabilities of Mycobacterium smegmatis vs Mycobacterium bovis BCG, using in silico and in vitro analysis methods
Author: Hooper, Tracy
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2008
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The recent resurgence of drug resistant strains of Mycobacterium tuberculosis, the causal agent of tuberculosis (TB) has strengthened the need for new anti-TB drugs. However, the accompanying experiments are lengthy due to the slow growth rate and pathogenic nature of the tubercle bacillus. Consequently a faster growing, nonpathogenic Mycobacterium would be ideal as a first screen in drug discovery. This project investigated metabolic features of M smegmatis to establish its utility as a first screen in the discovery of metabolic drug targets.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available