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Title: Oestrogen and Notch Signalling in the Regulation of Human Breast cancer Initiating cells.
Author: Harrison, Hannah
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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The transition from normal mammary development to the formation of aberrant cancerous tissues requires numerous mutations to occur. These alterations allow cancer cells to evade the usually strictly controlled pathways of survival, proliferation and self-renewal. The cell of origin for most tumours remains unknown but evidence that a sub-population of stem-like cells, termed cancer initiating cells, exists within solid cancers is strong.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Breast Cancer Genetic aspects