Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492845
Title: The effect of mechanical load on human mesenchymal stem cell differentiation
Author: Parker, Sian Marie
Awarding Body: Manchester University
Current Institution: University of Manchester
Date of Award: 2008
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Abstract:
Mesenchymal stem cells (MSCs) are multipotent stem cells, derived from bone marrow. Induction of MSC differentiation in vitro can occur with the appropriate culture conditions and more recently, the application of mechanical load has been implicated in MSC differentiation. Cells derived from MSCs, namely chondrocytes and osteoblasts have previously been shown to respond to mechanical load in vitro, and cartilage and bone are known to experience coinpressive tensile and shear forcesin vivo. A lack of mechanical load is known to affect MSC differentiation, however to date the effect of mechanical load on MSC differentiation potential has yet to be determined.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.492845  DOI: Not available
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