Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492470
Title: Cytokine gene polymorphism in non-infectious uveitis
Author: Atan, Deniz
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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Abstract:
Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance to uveitis has provided insights into the pathogenesis of uveitis, and might allow the prediction of patients who will have aggressive disease to allow tailoring of treatment to the individual.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.492470  DOI: Not available
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