Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492108
Title: Role of mitogen-activated protein kinases in the synergenic induction of matrix metalloproteinase-1 and - 13 following Interleukin-1- and Onconstatin M stimulation
Author: Jefferson, Matthew
Awarding Body: University of Newcastle upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
Availability of Full Text:
Access through EThOS:
Abstract:
One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is also known that oncostatin M (OSM) potentiates the effects of IL-1 in a synergistic manner. Although the phenomenon of synergy with IL-1+0SM is well documented, little data exist explaining the precise underlying mechanism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.492108  DOI: Not available
Share: