Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490111
Title: Chromosome Segregation during Mammalian Mitosis and Meiosis
Author: McGuinness, Barry E.
ISNI:       0000 0001 3624 5948
Awarding Body: Oxford
Current Institution: University of Oxford
Date of Award: 2008
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Abstract:
The spindle assembly checkpoint (SAC) functions to prevent anaphase onset until all chromosomes are correctly bi-oriented on the mitotic spindle and aligned at the metaphase plate. Cohesion between sister chromatids is essential for this biorientation. In animal cells, most cohesin is removed from chromosome arms during prophase and prometaphase. Cohesin at centromeres is refractory to removal at this stage and persists until metaphase, whereupon its Sccl subunit is cleaved by separase, which is thought to trigger anaphase. What protects centromeric cohesin from the prophase pathway? 1 show that depletion of Sgol by RNA interference in HeLa cells causes precocious loss of centromeric cohesin from chromosomes in prometaphase and a permanent cell cycle arrest, presumably due to inactivation or the spindle checkpoint.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.490111  DOI: Not available
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