Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490075
Title: Investigation of the signalling function of Dc SiGN
Author: Hodges, Ashleigh Marie
Awarding Body: Oxford
Current Institution: University of Oxford
Date of Award: 2008
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Abstract:
Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) is a C-type lectin receptor exclusively expressed by DCs and macrophages. It has been shown to bind and internalise a variety of pathogens such as HIV-1 and Mycobacterium tuberculosis, via conserved microbe-associated glycosylated moieties. It has also been demonstrated that HIV-1 can remain in an infectious state for days following internalisation by DC-SIGN, and infectious virions can then be transmitted to CD4+ T cells in trans.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.490075  DOI: Not available
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