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Title: Pharmacogenetics : implications for pharmacy practice
Author: Clemerson, Jessica
ISNI:       0000 0001 3558 9650
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2007
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Abstract:
The latter part of the 20th century has witnessed significant advances in the scientific understanding of the link between a person's genes and their response to medication. The term 'pharmacogenetics' was first used to describe clinical observations of inherited difference in response to medicines in the 1950s. Research in this field has gained momentum in recent years fuelled by the completion of the Human Genome Project in 2001. Aims The aim of this thesis was to determine the implications of developments in pharmacogenetics for community pharmacy practice. Methods A qualitative methodology was employed to generate data to address the research questions posed. Semi-structured interviews were used as a data collection method. Two samples of respondents were interviewed, one composed of community pharmacists and one of individuals in a position to influence their practice, referred to as 'influencers'. 2 'I ' Results Community pharmacists' knowledge and understanding of the term 'pharmacogenetics' and associated technological developments was found to be low, There was resistance to engaging in educational opportunities in this area, with the majority of pharmacists feeling that the subject has limited relevance to their current practice, Data were obtained from respondents involved in pharmacogenetic research and development which showed that the likely impact of pharmacogenetics .will, in the short term, be in very specific clinical areas. The concept of a 'pharmacogenetic revolution' in which. the prescribing process will be altered for all medicines was dismissed by all of these respondents. Conclusions Pharmacogenetics is influencing prescribing practice in certain clinical areas and this has the potential to increase as scientific understanding continues to move forward. This thesis shows that community pharmacists are inhibited in the way they are able to respond to new scientific and technological developments such as pharmacogenetics. Both internal and external barriers are faced by the profession when attempting to respond to changing healthcare arenas. Pharmacists should be encouraged to engage in educational opportunities around pharmacogenetics such that they can aid the transition of scientific developments into clinical practice.
Supervisor: Not available Sponsor: Not available
Qualification Name: University of Nottingham, 2007 Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.490056  DOI: Not available
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