Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489554
Title: Glioma Gentic profiling: The role of DNA repair and telomerase
Author: Patel, Rahima
Awarding Body: University of Central Lancashire
Current Institution: University of Central Lancashire
Date of Award: 2008
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Abstract:
Brain cancers inflict a disproportional burden of mortality upon sufferers. Due to difficulties of diagnosis and treatment, survival is low with most patients succumbing to the disease within a year of diagnosis. This has been the imperative factor to underpin some of the molecular mechanisms regulating gliomas and to aid with the development of novel disease biomarkers specifically targeting immortalisation (telomerase). Immortalisation not only requires telomerase but also an imbalance/inactivation of DNA repair functions such as 0⁶ methylguanine-DNAmethyltransferase (MGMT) which is a major obstacle with regards to glioma chemotherapy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.489554  DOI: Not available
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