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Title: Regulation of the human IL-3/GM-CSF locus
Author: Mirabella, Fabio
Awarding Body: Leeds
Current Institution: University of Leeds
Date of Award: 2008
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The human Interleukin-3 (IL-3) and Granulocyte-Macrophage Colony-Stimulating-Factor (GM-CSF) genes are two closely linked cytokine genes that are located within a conserved cytokine gene cluster. They are expressed in an inducible tissue-specific manner in a variety of haemopoietic cell types, and they contribute to the regulation of inflammatory responses arid haemopoiesis. For this reason their expression is strictly regulated. The experiments in this thesis describe an investigation into the factors and DNA elements involved in the control and regulation of these genes during T cell development. They focus in particular on the roles that DNase I hypersensitive sites (DHSs) and the nuclear proteins CTCF and RAD21 play within the GM-CSF/IL-3 gene locus.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available