Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717
Title: The role of thymidine kinase 1 in DNA repair
Author: McAllister, Katherine
Awarding Body: University of Ulster
Current Institution: Ulster University
Date of Award: 2007
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Abstract:
Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DNA damaging ',agents. This indicates a role of the enzyme in DNA repair processes. TKI could 'affect DNA repair through one of two hypothesised mechanisms:(a) through 'preferential repair, that is, the accelerated repair of actively transcribed genes compared to bulk DNA
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.487717  DOI: Not available
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