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Title: 0mega- 3 -po1yunsaturated fatty acids and atherosclerosis in systemic lupus erythematosus: cellular mechanisms and functional consequences.
Author: Wright, S. A.
Awarding Body: Queens -Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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Abstract:
Systemic lupus erythematosus~(SLE} is the archetypal autoimmune disease, with a wide range of clinical manifestations. Among the clinical challenges of SLE one of the most compelling is the high incidence of atherosclerosis in young women that is not fully explained by traditional Framingham risk factors. The ability to identify early those individuals at greatest risk of future vascular events would enable appropriate therapeutic intervention and risk factor modification to be employed. This work investigated vascular reactivity from different arterial beds using flow mediated dilation of the brachial artery, frequency domain analysis of Pulsed Doppler velocity wav~forms and radial artery applanation tonometry in 60 patients with SLE(without excess of conventional cardiovascular risk factors or major organ involvement} and compared to a control group. There were significant differences in the measures of endothelial function and arterial compliance in the SLE patients and there was also evidence of an alteration in the haemodynamics of the microcirculation through interrogation of the arterial pressure and flow waveforms. Fish oils or omega-3-polyunsaturated fatty acids (PUFAs) have been shown to improve endothelial function in disease states associated with atherosclerosis, and previous work has highlighted their potential beneficial effect in reducing disease activity in SLE. In this work, a double-blind placebo-controlled clinical trial of supplementation with 3gram of omega-3 PUFAs for 24 weeks in SLE patients resulted in a significant improvement in endothelial function and measures of disease activity. Furthermore, using the platelet as a model for endothelial free radical production, there was also a significant reduction in the oxidative stress marker, 8-isoprostane, with fish oils.
Supervisor: Not available Sponsor: Not available
Qualification Name: Queens -Belfast, 2008 Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.487588  DOI: Not available
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