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Title: A Strategy for Isotope Containment by Phase-tagging During Radiosynthesis and Towards the Total Synthesis of (+)-Lycorine
Author: Martin, Laetitia Janine
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2008
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Abstract:
The research described in this report covers two areas of investigation: 1) Devolatilisation of Isotopically Labelled Aromatics via Ge-based Phase-tagging: Isotopically labelled compounds are widely used within the pharmaceutical industry as trace quantities can be easily detected making them ideal for ADME studies on potential drug substances and their metabolites. Generic protocols for the phase-tagged synthesis of aryl-containing . intermediates from C4C]-bromobenzene (PhBr) and [14C]-phenol (PhOH) have been developed. The protocols involve devolatilisation of the above mentioned intermediates during the early stages of synthesis thus avoiding health, environme'1tal, regulatory and cost issues associated with incomplete isotopic containment. In particular, this chemistry has been developed in the context of the synthesis of N-Bn-4-acetylamino-4-phenylpiperidine, a key precursor to numerous neuroexcitatory pharmaceuticals including the Sanofi-Aventis neurokinin antagonist saredutant (SR-48968). The key elaboration steps are Ir-catalysed borylation, Suzuki cross-coupling and Mn-catalysed hydration. The approach constitutes a general strategy for the safe preparation of aryl-containing radiolabelled materials. 2) Towards the Total Synthesis of (+)-Lycorine: Work towards the development of a short asymmetric synthesis of the anti-tumour alkaloid (+)Iycorine using 1,4-addition to a cyclic enone and a refro-Cope elimination as key steps has been carried out. As part of this investigation, the diastereoselectivity of 1,4-addition of the lithium enolate of methyldithioacetate (.LMDTA) to 4-0-TBS-cyclohex-2-en-1-one was examined in detail. This study has revealed an intriguing temperature dependent stereodivergency of this process. By controlling the reaction conditions either frans- or cis-selective conjugate addition could be achieved, allowing access to stereochemically defined products previously difficult to access by any other means.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.486421  DOI: Not available
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