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Title: Evaluating the Reliability of FsT-Based Methods Used to Detect the Signature of Selection in Microsatellite Markers Linked to a Selection-Targeted Locus
Author: Singleton, Darran R.
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2007
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Abstract:
Random genetic drift affects the distribution of allele frequencies at neutral loci across the genome in a similar way, while selection acts at specific loci and leads to a departure from the expectations of genetic drift at those loci (Cavalli-Sforza 1966). All loci in a genome that do not respond to selection (either directly or through linkage to a selected locus) will have genealogies drawn from the same distribution. In principle it should be possible to identify loci responding to selection (either directly or through linkage) by comparing their level of genetic divergence to that of a neutral model. Lewontin and Krakauer proposed a test for identifying loci subject to selection that worked by estimating the variation in the degree of inbreeding among different loci through the parameter FST (Lewontin and Krakauer 1973). This work examines the effectiveness of a refined version of the method of Lewontin and Krakauer called Fdist (Beaumont and Nichols 1996). Fdist is used to analyse simulated data of microsatellite marker loci linked to a selection-targeted diallelic locus. The evolution of the loci under various symmetrical and asymmetrical island models is investigated by estimations of FsT• Distributions of FST at these target-linked sites· are then compared with observed rates of detection of those loci with Fdist. Results suggest that Fsr-based methods of detecting selection are generally reliable and may be sen,sitive to relatively low selection coefficients provided that population sizes are large and the markers are closely linked to the targets of selection.
Supervisor: Not available Sponsor: Not available
Qualification Name: University of Reading, 2007 Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.485585  DOI: Not available
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