Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438698
Title: Optical diffraction-based silicon sensors for the detection of DNA sequences
Author: Weld, Andrew Mark
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2007
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Abstract:
This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.438698  DOI: Not available
Keywords: TK Electrical engineering. Electronics Nuclear engineering ; QC Physics
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