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Title: Purinergic signalling in malignant melanoma
Author: White, Nicholas
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2005
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Malignant melanoma is an aggressive cancer that originates from melanocytes, the pigment producing cells of the skin. The incidence of melanoma is increasing and the outcome for patients with advanced disease remains poor. New therapies for melanoma are in urgently needed as no current systemic treatment is effective. Interactions between the nervous system and epidermal melanocytes have been suspected on the basis of their common embryological origin from the neural crest. Both melanocytes and melanomas are innervated by autonomic nerves with acetylcholine and noradrenaline acting as transmitter molecules. It is now well established that the purine nucleotide adenosine triphosphate (ATP) is a co-transmitter with noradrenaline in sympathetic nerves and with acetylcholine in parasympathetic nerves. ATP acts on extracellular receptors which have been characterised to consist of a number of subtypes. ATP acting on these receptors is involved with both rapid signalling in neurotransmission and also long term signalling in cell proliferation, differentiation and apoptosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available