Use this URL to cite or link to this record in EThOS:
Title: A study of the clinical characteristics of childhood type 2 diabetes with particular reference to ethnic differences in body composition and insulin sensitivity
Author: Ehtisham, Sarah.
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2005
Availability of Full Text:
Access from EThOS:
Type 2 diabetes is increasingly recognised in childhood, and is more common in South Asians and in girls in the UK. It is not clear how this increased risk relates to sex and ethnic differences in insulin sensitivity and body composition. The aims of this study were to describe the emergence of type 2 diabetes in UK children, and evaluate sex and ethnic differences in healthy adolescents to understand why certain children were more at risk of developing type 2 diabetes. I undertook a cross-sectional cohort study of adiposity and insulin sensitivity in healthy White UK and South Asian adolescents. I confirmed that South Asian adolescents were less insulin sensitive with a trend towards lower insulin sensitivity in girls. South Asian adolescents had significantly more body fat which was more centrally distributed. The sex-ethnic differences in insulin sensitivity were no longer seen on covariate analysis with body fat. South Asian children had higher leptin and lower adiponectin concentrations consistent with their increased adiposity. Ethnic differences in insulin sensitivity are associated with ethnic differences in body composition. South Asian adolescents are more insulin resistant, with more body fat, which may contribute to their increased risk of developing type 2 diabetes.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available