Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422859
Title: Platelet activation status in atherosclerotic disease
Author: Tan, Kiat Tsong
Awarding Body: University of Leicester
Current Institution: University of Leicester
Date of Award: 2005
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Abstract:
In order to provide more information on platelet activation that would be of interest to all clinicians involved in the care of the patient with atherosclerosis, this thesis sets out to provide data to either support or refute the following hypotheses. (1). Platelet activation in patients with stable coronary heart disease increases with the angiographic severity of disease. (2). Patients presenting with the acute manifestations of atherosclerosis have a greater degree of platelet activation than patients with stable disease. (3). Peripheral artery intervention results in the release of the cytokine, sCD40L, by platelets. (4). Platelet microparticle levels are higher in patients with Type 2 Diabetes who develop symptomatic macrovascular disease.;Using both flow cytometric and Enzyme Linked Immunosorbent Assay (ELISA) based measurements of platelet activation, this thesis confirms that platelet activation can be related to the clinical severity of atherosclerotic disease. In addition, the development of symptomatic atherosclerotic disease is associated with increased platelet microparticle levels. Peripheral artery angioplasty has also been shown to increase sCD40L release. However, there is no association between platelet activation status and the angiographic severity of coronary heart disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.422859  DOI: Not available
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