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Title: Endurance exercise : effects of high ambient temperature and central acting agents
Author: Silva Armada da Silva, Paulo A.
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2003
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The main intent of the work described in this thesis was to gain further insights into factors that affect performance during endurance exercise with particular emphasis on exercise in the heat. Five different studies are reported. The two first studies (Chapters 1 and 2) assessed the role of skin temperature modulating the negative impact of high ambient temperature. In Study Ia cap was developed that cooled the top of the head. The results showed, however, that cooling the top of the head had no effect on performance during a simulated cycling time trial conducted in the heat (35°C), despite the fact that the cold stimulation was effective in blunting prolactin secretion during exercise. In Study 2 the effect of body heating on the ratings of perceived exertion (RPE) was assessed during a short sub maximal exercise test in the heat. Body heating significantly increased RPEs from the start of exercise whereas it had no effect on thermal comfort. Cold stimulation of the face counteracted the effect of body heating on RPEs. Studies 3 and 4 (Chapters 4 and 5) explored the effect of high ambient temperature on the capacity to perform during subsequent exercise. A repeated exercise paradigm was used in Study 3. The results showed that, after a 2-h recovery, fatigue occurred earlier during a second bout of exercise in the heat (35°C) occurred earlier than in the first bout of exercise performed at the same ambient temperature. No changes in thermoregulation, plasma glucose, lactate, IL-6, prolactin or cortisol were seen that could explain the earlier fatigue onset. It was thought that exercise in the heat might affect hypothalamic neuroendocrine function and this was tested in Study 4 by conducting an insulin challenge 2h after either rest or strenuous exercise in the heat. However, no differences were seen in the magnitude of plasma prolactin and cortisol responses to acute hypoglycaemia. However, previous exercise in the heat increased reactivity of the autonomic innervation of the heart during the insulin test, as assessed by shifts in the power spectra of the R-R interval. The final study (Chapter 6) examined a possible mechanism for the ergogenic action of caffeine during prolonged exercise. Baclofen, a -aminobutyric acid B (GABAB) receptor agonist, was coingested with caffeine as a means of preventing the presumptive release of brain dopamine. The results, however, failed to demonstrate any effect of baclofen preventing the ergogenic effect of caffeine.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available