Studies of conformation and configuration using crystallographic methods
This Thesis demonstrates the use of the Cambridge Crystallographic Database for structure correlation studies in two very different fields. The first part of the Thesis (Chapters 2 and 3) is concerned with the systematic conformational analysis of medium-sized rings and satisfies the objectives of the study by: (i) applying novel classification techniques to the conformational descriptions of both the seven- and eight-membered rings, (ii) interpreting the results in terms of the relevant conformational hypersurface by locating the highly populated regions of that hypersurface and mapping the interconversion pathways, (iii) studying, modifying and improving the available methodologies for data analysis, and (iv) relating the conformational minima found using these methods to both the chemical environments of the fragments under investigation, and to energetic features of the hypersurface obtained by computational methods. The second major structure correlation experiment involves the analysis and description of 3-coordinated transition metal complexes using both simple geometrical models and group-theoretically based symmetry deformation coordinates. Non-bonded interactions will be seen to play a significant part in the geometry of the 3-coordinated fragment, and extrapolation of these results leads to the rationalisation of an addition/elimination scheme linking 4- and 2-coordinated fragments through the intermediate 3-coordinated species. Chapter 5 describes the crystallographic structure determinations of eight novel compounds: 3,5-cycloheptadienyl-3,5 dinitrobenzoate [C(_14)H(_12)O(_6)N(_2)]; a 34-membered diolide [C(_32)H(_60)O(_4)]; l-iodo-3-tosyloxy-propan-2-ane [C(_10)H(_11)O(_4)IS)]; 1β, 9 β -diacetyl- 7α-chloro-cis-hydrindane [C(_13)H(_19)O(_2)CI]; (R,R)-l,4-bis (2'-chloro-1 '-hydoxyethyl) benzene [C(_10)H(_12)O(_2)CI(_2)]; a fused penta-cyclic ring compound [C(_17)H(_14)]; 1,4 dibenzyl- 1,2,4,5-tetraazacyclohexane [C(_16) H(_20) N(_4)]; 1,5-di (2'-chloroacetoxy)-3,3-dimethyl-2,4- diphenyl-3-silapentane [C(_22)H(_26)O(_4) CI(_2) Si].