Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386634
Title: A biochemical and pharmacological characterisation of some endogenous and exogenous κ opioid ligands
Author: Bell, Katrina Margaret
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1994
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Abstract:
An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.386634  DOI: Not available
Keywords: Opioid peptides ; Receptor heterogeneity ; Dynorphin 1-8 ; [Leu5]enkephalin ; Opioid receptors ; Peptide metabolism ; Endopeptidases ; Vas deferens ; Brain Pharmacology Biochemistry
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