The regulation of chitin synthesis in Candida albicans
The control of synthesis of the cell-wall polymer chitin has been implicated as a crucial event in yeast - hyphal dimorphism of the pathogenic fungus, Candida albicans. This thesis presents evidence that suggests that the activity of the zymogenic enzyme, chitin synthase, is modulated by an endogenous activatory metalloprotease in vitro. The proposed activating protease is characterised and partially purified. A comparison of the intracellular proteolytic activity of yeast and hyphal cells suggest that hyphal cell may be nutrient-stressed compared to yeast cells.