Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382267
Title: Analytical studies on diazepam
Author: Barbour, Carol J.
Awarding Body: University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 1987
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Abstract:
Assay methods have been developed which are specific for the analysis of diazepam in the presence of formulation excipients, closely related degradation products and manufacturing impurities. The methods developed used difference ultraviolet spectrophotometry and HPLC. These methods have been applied to the analysis of diazepam in formulations and to investigate the reaction kinetics of the acid hydrolysis of diazepam. From analysis of both fresh and stored samples of formulations, it was seen that solid dosage forms showed no degradation, but degradation products were detected in liquid formulations. Advantages and disadvantages were seen for both techniques and criteria were established for the choice of method. The reaction kinetics of the degradation of diazepam was studied, using HPLC and GC. Previous workers had investigated the acid hydrolysis of diazepam using non-specific analytical methods. An attempt was made to repeat their work using the specific chromatographic methods described. From initial work, it appears that the results obtained are similar to those previously generated. Further work is required to investigate this more fully.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.382267  DOI: Not available
Keywords: Diazepam action analysis Pharmacology
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