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Title: Metabolic studies in leanness and obesity
Author: Rahman, Olaiwola
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 1986
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Metabolic rate and the proportion of carbohydrate, fat and protein oxidised at rest and during exercise were established in lean large eaters consuming 12843 + 1888 kJ per day and lean small eaters consuming 7090 +1568 kJ per day. Ther average resting metabolic rate in the lean large eaters was 330 + 47 ml oxygen/min. and in the lean small eaters was 285 + 54 ml oxygen/min. The average exercise metabolic rate in the lean large eaters was 1269 + 94 ml oxygen/min and in the lean small eaters was 1253 + 102 ml oxygen/min. In another group of lean large and small eaters, the average post prandial metabolic rate in lean large eaters consuming on average 13875 + 1562 kJ/day was 314 + 45 ml oxygen/min and in lean small eaters consuming 6372 + 1691 kJ/day was 278 + 40 ml oxygen/min. 24 hr energy expenditure in lean large eaters consuming on average 13005 ± 2004 kJ/day was 10191 + 34 kJ/day, and in lean small eaters consuming on average 7529 + 2228 kJ/day was 7156 + 461 kJ/day. However, none of these differences were statistically significant because of wide individual variation and the relatively small number of subjects. The adaptation of metabolic rate to a restricted energy intake was investigated in a group of obese women and a group of obese diabetic women. In the obese women, low metabolic rate observed during food restriction was associated with low nitrogen excretion. Long term metabolic rate measurements (up to 17 weeks) in the obese women who had lost weight indicated that metabolic rate was restored to previous values once feeding had commenced. Clinical studies indicated weight loss was achieved in the obese women without any damage to their health and there was a lowering of blood glucose levels in the obese diabetic women. A survey of 855 very low calorie diet (VLCD) users with relatively little clinical contact but helped by lay personnel confirmed the earlier clinical study that weight loss can readily be achieved by using a VLCD and that weight maintenance for up to a year was good probably because of the improved dietary behaviour as reported by the dieters. The proportion of dieters suffering from side-effects, such as halitosis, postural hypotension, constipation, weakness, hunger and headache were established, these sideeffects were not regarded as serious by most dieters. 88% claimed to feel well while on the diet and 71% claimed an Improvement in their health, while 2.8% consulted their doctor for symptoms which arose while they were on the diet.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Physiology Human physiology