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Title: Lipid and protein metabolism in the genetically obese Zucker rat
Author: Haggarty, P.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1983
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The aim of this study is to elucidate the metabolic basis for the abberant lipid and protein deposition observed in the young obese Zucker rat (fa/fa) by quantifying the fluxes through the major pathways involved in protein and lipid deposition and by ascertaining the contribution of dietary carbon to each of these 'end-products' in both obese and lean Zucker rats. The obese rat exhibits an accelerated rate of lipid deposition after weaning; this is partly the result of a greater lipid intake and a reduction in fatty acid catabolism but the most important factor is a greatly elevated rate of whole body fatty acid synthesis. It is postulated that the development of obesity in the fa/fa rat prior to weaning may be the result of an alteration in the partition of dietary fatty acids between storage as triacylglycerol and catabolism. The rate of protein deposition is significantly lower in the fa/fa rat before weaning and this is almost entirely a consequence of a decrease in muscle protein synthesis and deposition. After weaning there is a reduced rate of protein synthesis and degradation in the muscle and an increase in protein synthesis in the viscera of the obese rat. In the fa/fa rat a greater proportion of dietary carbon was incorporated into fatty acid while a smaller fraction was incorporated into non-essential amino acids. The alterations in protein metabolism in the ad libitum fed fa/fa rat are very similar to those found in fasted normal rats. Conversely, the unusual lipid metabolism of the fa/fa rat appears to reflect an excess of dietary nutrients. It is proposed that the metabolic aberrations present in the obese rat are consistent with the known metabolic effects of simultaneously high levels of circulating insulin and glucocorticoids such as are found in the obese rat.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry Biochemistry