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Title: The contribution of mechanical forces to the healing of wounds in the human skin
Author: Cacou, Crina
ISNI:       0000 0001 3513 5536
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1992
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The effect of mechanical forces in the healing of human wounds has been investigated. The study examined the effect of forces acting perpendicular to the plane of skin and parallel to it. The closure force of 17 surgical wounds made in favourable and unfavourable directions was measured and a relationship between the mechanical force acting across a wound and the final scar width became apparent. A technique to alter the local forces acting on a wound during healing was established. The results from eleven patients are presented and improved wound healing and prevention of hypertrophy was obtained. Examination of the piezoelectric properties of stressed skin samples gave the basis for a hypothesis to explain the contribution of mechanical forces at the cellular level. High levels of pressure were applied to 11 keloid and hypertrophic scars. The effectiveness of this treatment became apparent but problems were encountered with the application of high levels of pressure so far as the convenience of the patients was concerned. It became apparent that the cause of scarring is multifactorial with biological and mechanical factors being the main contributors. Modification of the mechanical forces involved can lead to an improved healing.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Medicine Medicine Biomedical engineering Biochemical engineering Wounds and injuries