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Title: In vitro and in vivo characterisation of buprenorphine and other long-lasting opioids
Author: Neilan, Claire L.
ISNI:       0000 0001 3440 6525
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 1999
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Buprenorphine is a promising medication for the treatment of opiate abuse. The pharmacology of buprenorphine has been studied in vitro using radioligand binding and [³⁵S]GTPγS assays, and in vivo using assays of antinociception in rodents. A number of compounds with potential similar pharmacology have also been characterised. These are an iso-morphinan pyrrolidine derivative, and long-lasting 14-aminomorphinones and codeinones, in particular clocinnamox (C-CAM), a pure μ-antagonist and methoclocinnamox (MC-CAM), which has some agonist properties.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Receptors; Irreversible antagonist; Drug abuse