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Title: Resident and infiltrating macrophage conditioning in the retina during inflammation
Author: Robertson, Morag Jean
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2003
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Experimental autoimmune uveoretinitis (EAU) is a retinal antigen-specific CD4+ T-cell-mediated inflammation of the retina.  However, T cells alone are insufficient to cause retinal damage.  During EAU, there is extensive tissue destruction and necrosis of resident ganglion cells and photoreceptors, which can in part be restricted by inhibiting nitric oxide, depleting macrophages or neutralising TNF-a activity.  Therefore, understanding and controlling macrophage function in inflammatory conditions, such as EAU, is of therapeutic importance.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Experimental autoimmune uveoretinitis Medicine Molecular biology Cytology Genetics Pharmacology