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Title: Synthesis and applications of novel oligosaccharide derivatives for slow release excipients
Author: Baddeley, Thomas C.
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2003
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O-Glycosidation and Knoeings-Knorr procedures were explored.  The synthesis of 6,6/-diamino-6,6/-dideoxy-a-a-trehalose was achieved and derivatives made.  Ester linked tri- and tetra-saccharides were synthesised and the self metathesis of alkyl mono and di-saccharide carried out. The glassy phase of these synthesised oligosaccharide derivatives were investigated for their use as controlled release excipients with two model drugs.  The process of devitrification of these glassy carbohydrate materials was explored.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Glycosidation Chemistry, Organic Biochemistry Pharmacology