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Title: Studies towards the total synthesis of novel opiate and Amaryllidaceae alkaloids.
Author: Harvey, Darren.
ISNI:       0000 0004 2750 6490
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 1999
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An approach to the total synthesis of novel opiate and Amaryllidaceae alkaloids is described. A rapid and efficient construction of the key intermediate [1.83], employing a palladium mediated cyclisation is presented. Studies towards the opiate ring skeleton utilising both nitrone and nitrile oxide [3+2] cycloadditions is investigated. Synthesis of the Amaryllidaceae alkaloids ring structure is described, involving a novel sublimation cyclisation protocol. The total synthesis of N, O-dimethyl norsanguinine is presented.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Morphine; Galanthamine; Cycloaddition