Studies towards the total synthesis of novel opiate and Amaryllidaceae alkaloids.
An approach to the total synthesis of novel opiate and Amaryllidaceae alkaloids is
described. A rapid and efficient construction of the key intermediate [1.83], employing
a palladium mediated cyclisation is presented. Studies towards the opiate ring skeleton
utilising both nitrone and nitrile oxide [3+2] cycloadditions is investigated. Synthesis of
the Amaryllidaceae alkaloids ring structure is described, involving a novel sublimation
cyclisation protocol. The total synthesis of N, O-dimethyl norsanguinine is presented.