Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278366
Title: An isotropic dosimetry probe for monitoring light in tissue, theoretical and experimental assessment
Author: Henderson, Brian
Awarding Body: Heriot-Watt University
Current Institution: Heriot-Watt University
Date of Award: 1990
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Abstract:
This thesis provides a unique method of producing an Isotropic dosimetry probe for monitoring light in highly scattering media, such as tissue. The requirement of such a probe is made apparent through a detailed review of current mathematical methods used to predict light distribution based on Radiative transfer theory and its subsequent solution under slab geometry. Initial methods of probe manufacture are discussed with the eventual technique involving a light cured polymer material providing the final method of construction. The resulting probe Is used to assess response uniformity and shadow effects. Mathematical modelling of the probe under spherical geometry is developed with experimental verification of boundary effects caused by refractive index mismatch presented for both internal and external Illumination. Typical application of the probe Is demonstrated resulting In direct measurement of backscattered reflectance and penetration depth. Indirect methods of measurement involving absorber modified penetration depths, reduced scattering co-efficients and an added absorber experiment are compared with theory. Further examination of the internal illumination of a probe In a scattering medium is related through theory and experiment to the optical properties of the surrounding medium. Continuing work on tissue . classification, fluorescence measurement including photodegradation, and a hyperthermia dosimetry probe is introduced.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.278366  DOI: Not available
Keywords: Lasers in surgery and medicine Optics Medicine Biology
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