Quantitative studies of biological damage induced using high intensity focused ultrasound
The objective of this project is to contribute to the development of therapeutic ultrasound
as a surgical technique for the "non-invasive" treatment of discrete liver tumours.
The design, focusing and calibration of high intensity sound sources is discussed, and
equipment used to treat specimens ranging in weight from a few grams up to several
hundred kilograms, is described.
The dependence of damage (lesion) dimensions in excised liver samples (at an ambient
temperature of 37°C) on the ultrasonic free-field spatial peak intensity (between 1350 and
5400 Wcm 2) and the depth of the focal plane beneath the tissue surface (between 10 and
30 mm) was investigated over a range of exposure times (1