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Title: Application of sodium perborate to organic synthesis.
Author: Kemp, Duncan.
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 1990
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This thesis describes the application of sodium perborate as a mild and convenient reagent to the oxidation of functional groups in organic synthesis. It is divided into seven chapters. Chapter 1 provides an introduction to the structural and synthetic chemistry of sodium perborate. Chapter 2 describes the application of sodium perborate to the oxidation of a wide range of aromatic aldehydes to the corresponding carboxylic acid. Chapter 3 details the use of sodium perborate as a reagent for the oxidative hydrolysis of aliphatic, aromatic and heterocyclic nitriles and as a substitute for hydrogen peroxide in the Payne Oxidation. Chapter 4 describes the application of sodium perborate to the N-oxidation of pyridines and quinolines. Chapter 5 describes the synthesis of (diacetoxyiodo)arenes from the parent iodoarene using sodium perborate and an attempt to use these (diacetoxyiodo)arenes in a new synthesis of peracids. Chapter 6 details the use of sodium perborate in the oxidation of various aliphatic, aromatic and heterocyclic sulphides to the corresponding sulphoxides and/or sulphones. Finally, Chapter 7 describes a number of miscellaneous reactions including amine, azoxyarene, alkene and alkyne oxidation and the deprotection of pheny1hydrazones by sodium perborate.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Organic chemistry Chemistry, Organic