Application of sodium perborate to organic synthesis.
This thesis describes the application of sodium perborate as
a mild and convenient reagent to the oxidation of functional
groups in organic synthesis. It is divided into seven chapters.
Chapter 1 provides an introduction to the structural and
synthetic chemistry of sodium perborate.
Chapter 2 describes the application of sodium perborate to
the oxidation of a wide range of aromatic aldehydes to the
corresponding carboxylic acid.
Chapter 3 details the use of sodium perborate as a reagent
for the oxidative hydrolysis of aliphatic, aromatic and heterocyclic
nitriles and as a substitute for hydrogen peroxide in the
Chapter 4 describes the application of sodium perborate to
the N-oxidation of pyridines and quinolines.
Chapter 5 describes the synthesis of (diacetoxyiodo)arenes
from the parent iodoarene using sodium perborate and an attempt
to use these (diacetoxyiodo)arenes in a new synthesis of
Chapter 6 details the use of sodium perborate in the oxidation
of various aliphatic, aromatic and heterocyclic sulphides to
the corresponding sulphoxides and/or sulphones.
Finally, Chapter 7 describes a number of miscellaneous reactions
including amine, azoxyarene, alkene and alkyne oxidation
and the deprotection of pheny1hydrazones by sodium perborate.