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Title: Protein folding
Author: Cohen, Fred E.
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 1980
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Recent studies of the relationship between protein sequence and protein structure are reviewed. A detailed discussion of past attempts to predict the structure of a protein from its amino acid sequence, the protein folding problem, is presented and the strengths and weaknesses of these methods are examined. The root-mean-square deviation is studied and a benchmark for structural comparisons is established. A combinatorial approach to the protein folding problem is outlined and its advantages over existing methods is discussed. Specific algorithms based on the combinatorial approach are developed and applied to a variety of proteins. The success of this approach in terms of the root-mean-square deviation benchmark as well as the drawbacks of this method are presented.
Supervisor: Phillips, David C. ; Richards, Frederic Middlebrook Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Protein folding ; Amino acid sequence ; Proteins ; Structure ; Structure-activity relationships Biochemistry