Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256084
Title: Studies on neural regulation of blood pressure in hypertension
Author: Floras, John Stanley
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 1981
Availability of Full Text:
Access through EThOS:
Full text unavailable from EThOS. Please try the link below.
Access through Institution:
Abstract:
Resetting of baroreceptor afferent firing in hypertensive animals, and the reduction in baroreflex regulation of the heart rate seen in man, are thought to be secondary to changes in vascular distensibility in hypertension. Diminished baroreflex sensitivity should be reflected in a withdrawal of inhibition of sympathetic nervous function. This hypothesis was investigated in 62 hypertensive subjects using three indirect indices of sympathetic nervous activity: (1) the haemodynamic responses to mental and physical exercise, (2) plasma noradrenaline concentrations at rest, and on exercise, and (3) the beat-to-beat variability of waking ambulatory blood pressure. Subjects with diminished baroreflex sensitivity (1) achieved higher maximum mean arterial blood pressures during four different exercises, and greater absolute increases in blood pressure when bicycling, (2) tended (P
Supervisor: Jones, John Vann Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.256084  DOI: Not available
Keywords: Blood pressure ; Regulation ; Hypertension ; Baroreflexes Human physiology
Share: