Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254925
Title: The in vitro interaction between the surfaces of biocompatible materials and human leucocytes
Author: Doyle, Christiana
ISNI:       0000 0000 8278 7433
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 1980
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Abstract:
An in vitro study has been conducted in order to improve the understanding of the interaction between lymphocytes and inplant materials. The uptake of cellular thymidine for DMA synthesis was used to monitor the cellular responses, in conjunction with microscopy. Material ellutions stimulated the uptake of thymidine by cells, whereas solid material caused an inhibition of thymidine uptake. This inhibition was seen both in PHA-stimulated cultures and in cultures in the presence of materials only. Inhibition of thymidine uptake was found to be caused indirectly by contact with material surfaces and directly by an active cell secretion, produced in response to the materials. It was postulated that this active cell secretion was a lymphotoxin.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.254925  DOI: Not available
Keywords: Bioengineering & biomedical engineering
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